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Froelich, Christopher
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Concept Cytoplasmic Granules
Academic Article New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.
Academic Article An antimicrobial activity of cytolytic T cells mediated by granulysin.
Academic Article Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays.
Academic Article Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors.
Academic Article Purification and use of granzyme B.
Academic Article Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
Academic Article Cell death-associated translocation of plasma membrane components induced by CTL.
Academic Article Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.
Academic Article Granule-associated serine proteases: granzymes might not just be killer proteases.
Academic Article Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein.
Academic Article Human granzyme B is essential for DNA fragmentation of susceptible target cells.
Academic Article Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
Academic Article Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.
Academic Article Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
Academic Article Rapid purification of cationic granule proteases: application to human granzymes.
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